Advanced Functional Materials
Nanoparticles enable selective protein removal in animals
Proof-of-concept animal experiments used DNA-carrying particles for tumor- and brain-targeted gene delivery, with encouraging signals in selected cancer and…Proof-of-concept animal experiments used DNA-carrying particles for tumor- and brain-targeted gene delivery, with encouraging signals in selected cancer and neurodegeneration models.
Animal studyInterventions
Who was studiedAnimals in preclinical models
What changedSystemically administered nanoparticles depleted target proteins in preclinical animal models
The catchOff-target transcriptional changes are a proxy for unintended protein depletion