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Endogenous protein abundance

There is 1 paper on endogenous protein abundance in aging research: none in people yet, 1 in animals. The newest story, Nov 4, 2026: “Nanoparticles enable selective protein removal in animals”.

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1 new paper in 30 daysSee all 1 papers on endogenous protein abundance

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Gene-encoded TRIM21 degraders

downin animals1

1 study

  1. Gene-encoded TRIM21 degraders decrease endogenous protein abundance (preclinical models).

    “systemic administration yielded proof‐of‐concept tumor‐ and brain‐targeted gene delivery, target‐protein depletion in preclinical models”

    Animalspreclinical modelsplasmids delivered by targeted lipid–polymer hybrid nanoparticles

    Nanoparticles enable selective protein removal in animals

    Advanced Functional Materials

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Advanced Functional Materials

Nanoparticles enable selective protein removal in animals

Proof-of-concept animal experiments used DNA-carrying particles for tumor- and brain-targeted gene delivery, with encouraging signals in selected cancer and…Proof-of-concept animal experiments used DNA-carrying particles for tumor- and brain-targeted gene delivery, with encouraging signals in selected cancer and neurodegeneration models.

Animal studyInterventions
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