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Targeted demethylation

Targeted demethylation has been studied in 1 paper since 2026: none in people yet, 1 in cells; 1 in the past year. No study of it in people or animals has been published yet. The newest story, Nov 5, 2026: “Gene silencing lasts and partly reverses in human blood stem cells”.

Intervention

1 paper studies it1 findingUpdated

1 new paper in 30 daysSee all 1 papers on targeted demethylation

At a glance

The findings reach cells, none yet in people. 1 lab.

Cells: a single group. Worms or flies, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Funders: Howard Hughes Medical Institute and 1 more
  • Cells1

What did studies of targeted demethylation find?

1

Studies of targeted demethylation measured 1 outcome; the most studied are ITGB3 silencing (1 study).

ITGB3 silencing

downin human cells1

1 study

  1. Targeted demethylation decreases ITGB3 silencing in human cells after DNA methylation-based epigenome editing.

    “and was partially reversed through targeted demethylation at this locus.”

    Cellsafter DNA methylation-based epigenome editing

    Gene silencing lasts and partly reverses in human blood stem cells

    Cell stem cell

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 11 paper in 12 months
Cell Stem Cell

Gene silencing lasts and partly reverses in human blood stem cells

Silencing of a platelet-related gene remained stable four months after human stem cells were transplanted into mice.Silencing of a platelet-related gene remained stable four months after human stem cells were transplanted into mice.

Human cell studyInterventions
Paper

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