Synaptopathic noise
3 findings
- 1 lab in 1 country
- Funders: National Institute on Deafness and Other Communication Disorders and 1 more
Outcomes
3Inner hair cell degeneration
upin mice1
1 study
Inner hair cell degeneration
upin mice1
Synaptopathic noise increases inner hair cell degeneration in mice.
“Inner hair cells showed no losses at 1 month, whereas, at later ages, noise-exposed ears showed enhanced degeneration in the extreme base.”
Animalslater ages after noise exposurecochlea
Hearing research27 Jun 2026
ANF peripheral axons
downin mice1
1 study
ANF peripheral axons
downin mice1
Synaptopathic noise decreases ANF peripheral axons in mice (only half that of ribbon loss).
“Peripheral axon loss was markedly delayed and did not exceed age-matched controls until 6 months. Even at the longest survival, axonal loss remained only half that of ribbon loss.”
Animalssynaptopathic noise exposurecochleaup to 2 years
Hearing research27 Jun 2026
Synaptic ribbons
downin mice1−50% loss
1 study
Synaptic ribbons
downin mice1−50% loss
Synaptopathic noise decreases synaptic ribbons in mice (50% loss).
“We exposed CBA/CaJ mice to a synaptopathic 8-16 kHz noise stimulus producing an immediate 50% loss of inner hair cell synapses, with minimal post-exposure recovery.”
Animalscochleaimmediate
Hearing research27 Jun 2026