Spice program

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Human trial1

Outcomes

Physical function

upin humans1

1 study

Spice program improves physical function in humans.
“Significant mean differences were also observed for physical outcomes for people with dementia and care partners”
Human trialdementia12 weeks
The Sustainable Personalised Interventions for Cognition, Care, and Engagement (SPICE) program: Pre and post outcomes of a multicomponent intervention for people with dementia and care partners
AAIC 2025 abstract26 Dec 2025

Neuropsychiatric symptoms

downin humans1

1 study

Spice program decreases neuropsychiatric symptoms in humans (mean decrease of 1.76 points (95% CI [.80, 2.72])).
“NPI-Q scores decreasing by a mean of 1.76 points (95% CI [.80, 2.72])”
Human trialdementia12 weeksn = 91
The Sustainable Personalised Interventions for Cognition, Care, and Engagement (SPICE) program: Pre and post outcomes of a multicomponent intervention for people with dementia and care partners
AAIC 2025 abstract26 Dec 2025

Cognitive function

upin humans1

1 study

Spice program improves cognitive function in humans (mean 1.61 points (95% CI [.35, 2.87])).
“ACE-III mean scores increasing by 1.61 (95% CI [.35, 2.87])”
Human trialdementia12 weeksn = 91
The Sustainable Personalised Interventions for Cognition, Care, and Engagement (SPICE) program: Pre and post outcomes of a multicomponent intervention for people with dementia and care partners
AAIC 2025 abstract26 Dec 2025

Quality of life

upin humans1

1 study

Spice program improves quality of life in humans (mean 4.4 points (95% CI [2.36, 6.44])).
“DEMQOL scores increasing by a mean of 4.4 points (95% CI [2.36, 6.44])”
Human trialdementia12 weeksn = 91
The Sustainable Personalised Interventions for Cognition, Care, and Engagement (SPICE) program: Pre and post outcomes of a multicomponent intervention for people with dementia and care partners
AAIC 2025 abstract26 Dec 2025

Latest

1 in 12 months

AAIC 2025 Abstract26 Dec

The Sustainable Personalised Interventions for Cognition, Care, and Engagement (SPICE) program: Pre and post outcomes of a multicomponent intervention for people with dementia and care partners

Non-randomised trial in peopleDementia

Paper

Spice program

Outcomes

Latest

The Sustainable Personalised Interventions for Cognition, Care, and Engagement (SPICE) program: Pre and post outcomes of a multicomponent intervention for people with dementia and care partners

Related