Sodium citrate

1. Sodium citrate decreases calcium in rats (1.0 +/- 0.12 vs 1.8 +/- 0.18 mg/24 h urine, P less than 0.05).

   “Urinary calcium in SHRSP given sodium citrate was significantly decreased (1.0 +/- 0.12 vs 1.8 +/- 0.18 mg/24 h urine, P less than 0.05).”

   Animalsin stroke-prone spontaneously hypertensive rats compared with sodium chloridedrinking waterurine24 hn = 10

   Chloride ion ingested with sodium affects the development of cerebral lesions in stroke-prone spontaneously hypertensive rats

   Clinical and experimental pharmacology & physiology·1 Jun 1991

More on Calcium

1. Sodium citrate has no effect on hypertension in rats.

   “their development of hypertension was not different from SHRSP given sodium chloride”

   Animalsin stroke-prone spontaneously hypertensive rats compared with sodium chloridedrinking watern = 10

   Chloride ion ingested with sodium affects the development of cerebral lesions in stroke-prone spontaneously hypertensive rats

   Clinical and experimental pharmacology & physiology·1 Jun 1991

More on Hypertension

1. Sodium citrate extends lifespan in rats (336 +/- 28 vs 246 +/- 26 days, P less than 0.05).

   “The life span was significantly extended in SHRSP given sodium citrate (336 +/- 28 vs 246 +/- 26 days, mean +/- s.e.m., P less than 0.05)”

   Animalsin stroke-prone spontaneously hypertensive rats compared with sodium chloridedrinking watern = 10

   Chloride ion ingested with sodium affects the development of cerebral lesions in stroke-prone spontaneously hypertensive rats

   Clinical and experimental pharmacology & physiology·1 Jun 1991