Social exposome

2 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 4 countries

Funders: Agencia Nacional de Investigación y Desarrollo and 6 more

Humans2

Outcomes

Neuropsychiatric symptoms

upin humans1

1 study

Social exposome increases neuropsychiatric symptoms in humans.
“In people with dementia, the more adverse the social exposome, the lower the cognitive functioning and functional ability, and increased neuropsychiatric symptoms.”
Humansin people with dementian = 2,211
Social exposome and brain health outcomes of dementia across Latin America
AAIC 2025 abstract24 Dec 2025

Cognitive function

downin humans1

1 study

Social exposome impairs cognitive function in humans.
“Structural equation modeling of cumulative social exposome shown significant associations with poorer cognition in healthy aging”
Humanshealthy agingn = 2,211
Social exposome and brain health outcomes of dementia across Latin America
AAIC 2025 abstract24 Dec 2025

Associations

Brain structural and connectivity alterations

upin humans2

2 studies

Social exposome is associated with brain structural and connectivity alterations in humans.
“Brain structural and connectivity alterations were associated with more adverse social exposome in dementia‐sensitive and cerebellar regions”
Humansin AD and FTLDn = 2,211
Social exposome and brain health outcomes of dementia across Latin America
AAIC 2025 abstract24 Dec 2025
Social exposome is associated with brain structural and connectivity alterations in humans.
“brain structural and connectivity alterations in frontal-temporal-limbic and cerebellar regions”
Humansdementiabrain
Social exposome and brain health outcomes of dementia across Latin America
Nature communications11 Sep 2025

Physical function

downin humans1

1 study

Social exposome is associated with physical function in humans.
“In dementia, more complex exposomes correlate with lower cognitive and functional performance”
Humansdementia
Social exposome and brain health outcomes of dementia across Latin America
Nature communications11 Sep 2025

Cognitive function

downin humans1

1 study

Social exposome is associated with cognitive function in humans.
“Adverse exposomes associate with poorer cognition in healthy aging.”
Humansn = 2,211
Social exposome and brain health outcomes of dementia across Latin America
Nature communications11 Sep 2025