Small molecule activators of SIRT1

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Institute on Aging

Animals1

Outcomes

Insulin sensitivity

upin mice1upin rats1

1 study

Small molecule activators of SIRT1 improves insulin sensitivity in rats.
“In Zucker fa/fa rats, hyperinsulinaemic-euglycaemic clamp studies demonstrate that SIRT1 activators improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver.”
Animalsin Zucker fa/fa rats
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Nature29 Nov 2007
Small molecule activators of SIRT1 improves insulin sensitivity in mice.
“In diet-induced obese and genetically obese mice, these compounds improve insulin sensitivity, lower plasma glucose, and increase mitochondrial capacity.”
Animalsin diet-induced obese and genetically obese mice
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Nature29 Nov 2007

Plasma glucose

downin mice1

1 study

Small molecule activators of SIRT1 decreases plasma glucose in mice.
“In diet-induced obese and genetically obese mice, these compounds improve insulin sensitivity, lower plasma glucose, and increase mitochondrial capacity.”
Animalsin diet-induced obese and genetically obese mice
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Nature29 Nov 2007

Latest

Nature29 Nov