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Sleep problems

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Humans1

Associations

2

Social isolation

upin humans1

1 study

  1. Sleep problems predict social isolation in humans (β .024 (95% CI 0.001–0.046) to .027 (95% CI 0.002–0.052)).

    “and the reverse association also observed (β = .024, 95% CI [0.001, 0.046], to .027, 95% CI [0.002, 0.052]).”

    Humans10 years

    Loneliness, social isolation, and sleep problems: Findings from a 10-year longitudinal study of Chinese middle-aged and older adults

    Health psychology : official journal of the Division of Health Psychology, American Psychological Association29 Sep 2025

Loneliness

upin humans1

1 study

  1. Sleep problems predict loneliness in humans (β .032 (95% CI 0.019–0.046) to .041 (95% CI 0.024–0.057)).

    “sleep problems predicted later loneliness, β = .032, 95% confidence interval (CI) [0.019, 0.046], to .041, 95% CI [0.024, 0.057]”

    Humans10 yearsn = 7,622

    Loneliness, social isolation, and sleep problems: Findings from a 10-year longitudinal study of Chinese middle-aged and older adults

    Health psychology : official journal of the Division of Health Psychology, American Psychological Association29 Sep 2025

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