Single-pill combination therapy through team-based care

Q: What did studies of single-pill combination therapy through team-based care find?

Studies of single-pill combination therapy through team-based care measured 2 outcomes; the most studied are serious adverse events (1 study) and systolic blood pressure (1).

Single-pill combination therapy through team-based care has been studied in 1 paper since 2026: 1 trial in people; 1 in the past year. The newest story, Nov 9, 2026: “Combination-pill care program lowered blood pressure”.

Intervention

1 paper studies it2 findingsUpdated Nov 8, 2026

1 new paper in 30 daysSee all 1 papers on single-pill combination therapy through team-based care

At a glance

The findings reach people, from one lab or study. 1 lab.

“Serious adverse events (death and hospitalization) occurred at similar frequencies in the intervention (7.9%) and standard care (9.9%) groups.”

Implementation of Single-Pill Combination Therapy Through Team-Based Care for Hypertension Control in Resource-Constrained Settings: A Cluster Randomized Clinical TrialJAMA2026doi:10.1001/jama.2026.24169

None of its findings points the other way.

1 lab

Human trial1

Studies in people

1 study gave single-pill combination therapy through team-based care to people and measured what changed.

What changed	Design	People	Source
down: Decreases systolic blood pressureBetween-group difference in change: -10.1 mm Hg (95% CI, -13.3 to -6.9 mm Hg; P < .001) no change: Has no effect on serious adverse events7.9% in the intervention group versus 9.9% in the standard care group	Randomized trial18 months	1,574 peopleBothMean 61.4 yearsMidlife adults; Adults with uncontrolled hypertension in Colombia and Jamaica	JAMA, Nov 8, 2026

down: Decreases systolic blood pressureBetween-group difference in change: -10.1 mm Hg (95% CI, -13.3 to -6.9 mm Hg; P < .001)

no change: Has no effect on serious adverse events7.9% in the intervention group versus 9.9% in the standard care group

Randomized trial18 months

1,574 peopleBothMean 61.4 yearsMidlife adults; Adults with uncontrolled hypertension in Colombia and Jamaica

JAMA, Nov 8, 2026

What did studies of single-pill combination therapy through team-based care find?

Studies of single-pill combination therapy through team-based care measured 2 outcomes; the most studied are serious adverse events (1 study) and systolic blood pressure (1).

Serious adverse events

no changein humans1

1 study

Single-pill combination therapy through team-based care showed no clear effect on serious adverse events in humans (Adults with uncontrolled hypertension; compared with standard care) (7.9% in the intervention group versus 9.9% in the standard care group).
“Serious adverse events (death and hospitalization) occurred at similar frequencies in the intervention (7.9%) and standard care (9.9%) groups.”
Human trialAdults with uncontrolled hypertension; compared with standard care
Combination-pill care program lowered blood pressure
JAMANov 8, 2026

Systolic blood pressure

downin humans1

1 study

Single-pill combination therapy through team-based care decreases systolic blood pressure in humans (Adults with uncontrolled hypertension in Colombia and Jamaica; compared with standard care) (Between-group difference in change: -10.1 mm Hg (95% CI, -13.3 to -6.9 mm Hg; P < .001)).
“Implementing single-pill combination therapy through team-based care significantly reduced blood pressure over 18 months among adults with uncontrolled hypertension in Colombia and Jamaica.”
Human trialAdults with uncontrolled hypertension in Colombia and Jamaica; compared with standard care18 monthsn = 1,574
Combination-pill care program lowered blood pressure
JAMANov 8, 2026

Latest

1 paper in 12 months

JAMANov 9

Combination-pill care program lowered blood pressure

The combined program reduced the upper blood pressure reading by 10.1 millimeters of mercury more than standard care over 18 months.The combined program reduced the upper blood pressure reading by 10.1 millimeters of mercury more than standard care over 18 months.

Randomized trial · 1,574 peopleHypertension

Paper