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Silencing ec-projecting cholinergic neurons

Exposure

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Alzheimer's Foundation of America and 2 more
  • Humans1

Outcomes

1

Cognitive function

downin mice1

1 study

  1. Silencing ec-projecting cholinergic neurons impair cognitive function in mice.

    “Silencing EC-projecting cholinergic neurons in young, healthy mice during the object-location memory task impairs object recognition performance, mimicking aging.”

    Animalshealthy

    Loss of cholinergic input to the entorhinal cortex is an early indicator of cognitive impairment in natural aging of humans and mice

    Research square23 Jan 2024Preprint

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