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Running wheel exercise

Intervention

2 papers study it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Arthritis Australia and 5 more
  • Animals2

Outcomes

1

Balance beam performance

no changein mice1

1 study

  1. Running wheel exercise has no effect on balance beam performance in mice.

    “aged mice (27-28 months) that received continuous access to a running wheel for 4 weeks did not improve when retested.”

    AnimalsRetesting following vestibular stimulationcontinuous access4 weeks

    Motor Performance is Impaired Following Vestibular Stimulation in Ageing Mice

    Frontiers in aging neuroscienceFeb 3, 2016

Associations

1

Cartilage fluid-solid interactions

mixedin mice1

1 study

  1. Running wheel exercise is associated with cartilage fluid-solid interactions in mice.

    “Running caused substantial changes in fluid-solid interactions in aggrecanase-resistant mice, suggestive of tissue degradation.”

    Animalsaggrecanase-resistant micedistal femur cartilage

    Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse

    Journal of biomechanicsApr 3, 2016

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