Risk-stratified screening

Risk-stratified screening has been studied in 2 papers since 2026: 1 observational study in people, 1 review; 2 in the past year. The newest story, Oct 31, 2026: “Risk scores shift breast screening advice in Asian women”.

Exposure

2 papers study it2 findingsUpdated Oct 30, 2026

2 new papers in 30 daysSee all 2

“Risk stratification combining PRS and Gail model captured 68-69% of cases aged 40-49 in SGBCC (n = 1,184) and MyBrCa (n = 1,122), versus ~ 54% by PRS alone.”

Polygenic and classical risk integration reshapes breast cancer screening recommendations in 9,761 Asian womenBMC medicine2026doi:10.1186/s12916-026-05334-5

None of its findings points the other way.

1 lab in 1 country

Funder: Precision Health Research, Singapore

Humans1

What did studies of Risk-stratified screening find?

Studies of Risk-stratified screening measured 2 outcomes; the most studied are breast cancer case capture (1 study) and Mammography screening eligibility (1).

Breast cancer case capture

upin humans1

1 study

Risk-stratified screening is linked with higher breast cancer case capture in humans (SGBCC and MyBrCa; compared with PRS alone) (68-69% versus ~ 54% by PRS alone).
“Risk stratification combining PRS and Gail model captured 68-69% of cases aged 40-49 in SGBCC (n = 1,184) and MyBrCa (n = 1,122), versus ~ 54% by PRS alone.”
HumansSGBCC and MyBrCa; compared with PRS alonefemales
Risk scores shift breast screening advice in Asian women
BMC medicineOct 30, 2026

Mammography screening eligibility

downin humans1

1 study

Risk-stratified screening is linked with lower mammography screening eligibility in humans (Healthy women currently recommended annual mammography) (776 (38.7%) assigned no screening; 960 (47.9%) assigned biennial screening).
“risk stratification downgraded 776 (38.7%) to no screening and 960 (47.9%) to biennial”
HumansHealthy women currently recommended annual mammographyfemalesn = 2,003
Risk scores shift breast screening advice in Asian women
BMC medicineOct 30, 2026

Latest

2 papers in 12 months

BMC MedicineOct 31

Risk scores shift breast screening advice in Asian women

Among 2,003 healthy women aged 40–49 advised annual mammograms, risk assessment reassigned 38.7% to no screening and 47.9% to screening every two years.Among 2,003 healthy women aged 40–49 advised annual mammograms, risk assessment reassigned 38.7% to no screening and 47.9% to screening every two years.

Cohort · 2,003 peopleBiomarkers

Paper

Frontiers in MedicineOct 30

Evolution of Colorectal Cancer Screening Technologies and Health Economic Evaluation: Optimization Strategies Based on an Economic Gradient and Dynamic Risk Stratification

Accepted, not yet published: reviewColorectal cancer