Reelin

Reelin decreases intrinsic hyperexcitability of CA1 pyramidal neurons in mice.

“correlated with reduced intrinsic hyperexcitability of CA1 pyramidal neurons”

Animalsin Ndel1 CKO mice treated with ReelinCA1 hippocampus

Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration

Cerebral cortex (New York, N.Y. : 1991)·30 Jul 2020

Reelin extends lifespan in mice (twice as long).

“when treated with Reelin, Ndel1 CKO animals that die from an epileptic phenotype, live twice as long as nontreated, or vehicle-treated CKO animals”

Animalsin Ndel1 CKO mice that die from an epileptic phenotype

Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration

Cerebral cortex (New York, N.Y. : 1991)·30 Jul 2020

Reelin improves spatial learning and memory in mice.

“a single injection of Reelin protein in the hippocampus of Ndel1 CKO mice improves spatial learning and memory function”

Animalsin Ndel1 CKO micehippocampus

Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration

Cerebral cortex (New York, N.Y. : 1991)·30 Jul 2020