Psalmotoxin 1

1. Psalmotoxin 1 decreases cellular senescence in mice.

   “intra-articular administration of PcTx-1 reduced articular cartilage destruction and chondrocytes senescence in OA mice”

   Animalsin OA miceintra-articular administrationarticular cartilage

   ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18

   International immunopharmacology·Sep 1, 2023

2. Psalmotoxin 1 decreases cellular senescence in rat cells.

   “These effects were inhibited by ASIC1a-specific blocker psalmotoxin-1 or ASIC1a-short hairpin RNA respectively in chondrocytes.”

   Cellsacid-induced chondrocytes

   Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation

   Biochemical pharmacology·May 25, 2022

More on Cellular senescence

1. Psalmotoxin 1 decreases osteoarthritis in mice.

   “In vivo, intra-articular administration of PcTx-1 reduced articular cartilage destruction and chondrocytes senescence in OA mice”

   Animalsin OA miceintra-articular administrationarticular cartilage

   ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18

   International immunopharmacology·Sep 1, 2023

More on Osteoarthritis