Postnatal overfeeding

1. Postnatal overfeeding increases inflammation in mice.

   “This is accompanied by a higher PAT mass with increased inflammatory status.”

   Animalspericardial adipose tissuemales

   Short-Term Postnatal Overfeeding Induces Long-Lasting Cardiometabolic Syndrome in Mature and Old Mice Associated with Increased Sensitivity to Myocardial Infarction

   Molecular nutrition & food research·Jun 27, 2024

More on Inflammation

1. Postnatal overfeeding increases infarct size in mice (27-34%).

   “as well as a 27-34% increase in infarct size”

   Animalsmyocardial ischemia-reperfusion injurymales

   Short-Term Postnatal Overfeeding Induces Long-Lasting Cardiometabolic Syndrome in Mature and Old Mice Associated with Increased Sensitivity to Myocardial Infarction

   Molecular nutrition & food research·Jun 27, 2024

1. Postnatal overfeeding impairs left ventricular ejection fraction in mice (-10%).

   “and a 10% decrease in left ventricular ejection fraction throughout their lifespan”

   Animalsmales

   Short-Term Postnatal Overfeeding Induces Long-Lasting Cardiometabolic Syndrome in Mature and Old Mice Associated with Increased Sensitivity to Myocardial Infarction

   Molecular nutrition & food research·Jun 27, 2024

More on Left ventricular ejection fraction

1. Postnatal overfeeding increases body weight in mice (10-20%).

   “PNOF mice exhibit an early and persistent 10-20% increase in body weight”

   Animalsmales

   Short-Term Postnatal Overfeeding Induces Long-Lasting Cardiometabolic Syndrome in Mature and Old Mice Associated with Increased Sensitivity to Myocardial Infarction

   Molecular nutrition & food research·Jun 27, 2024