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Positive minds strong bodies-enhanced

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Institute on Aging and 1 more
  • Human trial1

Outcomes

3

Hopkins Symptom Checklist-25

no changein humans1

1 study

  1. Positive minds strong bodies-enhanced has no effect on hopkins Symptom Checklist-25 in humans.

    “There were no effects on LLFDI or HSCL-25 scores, nor interaction effects by race and ethnicity.”

    Human trialCompared with usual caren = 427

    Combined Psychoeducational and Exercise Training Intervention to Improve Mental Health and Physical Functioning in Late-Life: A Randomized Controlled Trial

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry30 Oct 2025

Late-Life Functioning and Disability Instrument

no changein humans1

1 study

  1. Positive minds strong bodies-enhanced has no effect on late-Life Functioning and Disability Instrument in humans.

    “There were no effects on LLFDI or HSCL-25 scores, nor interaction effects by race and ethnicity.”

    Human trialCompared with usual caren = 427

    Combined Psychoeducational and Exercise Training Intervention to Improve Mental Health and Physical Functioning in Late-Life: A Randomized Controlled Trial

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry30 Oct 2025

Short Physical Performance Battery

upin humans1

1 study

  1. Positive minds strong bodies-enhanced improves short Physical Performance Battery in humans (Standardized difference 0.28; 95% CI 0.07–0.49).

    “Intervention participants showed improved SPPB scores in month 12 (standardized difference, 0.28; 95% CI, 0.07-0.49)”

    Human trialDepression or anxiety symptoms and mobility limitations; compared with usual careTen psychoeducational and 36 exercise sessions over 6 months12 monthsn = 427

    Combined Psychoeducational and Exercise Training Intervention to Improve Mental Health and Physical Functioning in Late-Life: A Randomized Controlled Trial

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry30 Oct 2025

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