Poly-d,l-lactic acid

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

Hair coverage

upin mice1

1 study

Poly-d,l-lactic acid increases hair coverage in mice.
“PDLLA administration led to increased hair follicle number, diameter, and length, as well as prolonged anagen and greater hair coverage.”
Animalsfillerskin
Poly-D,L-Lactic Acid Filler Increases Hair Growth by Modulating Hair Follicular Stem Cells in Aged Skin
Cells19 Dec 2025

Wnt signaling molecule expression

upin mouse cells1

1 study

Poly-d,l-lactic acid increases Wnt signaling molecule expression in mouse cells.
“PDLLA upregulated Wnt signaling molecules (Wnt3a, Wnt10b, and β-catenin)”
Cells
Poly-D,L-Lactic Acid Filler Increases Hair Growth by Modulating Hair Follicular Stem Cells in Aged Skin
Cells19 Dec 2025

More on Wnt signaling molecule expression

HGF and IGF-1 secretion

upin mouse cells1

1 study

Poly-d,l-lactic acid increases HGF and IGF-1 secretion in mouse cells.
“PDLLA increased Piezo1 expression and activity in senescent macrophages, enhancing M2 polarization and secretion of HGF and IGF-1.”
Cellssenescent macrophagesmacrophage
Poly-D,L-Lactic Acid Filler Increases Hair Growth by Modulating Hair Follicular Stem Cells in Aged Skin
Cells19 Dec 2025

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Cells9 Jan