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Placenta-derived mesenchymal stem cells

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Research Foundation of Korea
  • Animals1

Outcomes

3

Estrogens

upin mice1

1 study

  1. Placenta-derived mesenchymal stem cells increase estrogens in mice.

    “Additionally, estrogen levels were elevated, bone formation markers were upregulated, and bone resorption markers were downregulated.”

    Animalsin an estrogen-deficiency-induced osteoporosis mouse model

    Increased BMP/SMAD Signaling by PD-MSCs Promotes Bone Formation in an Ovariectomized Mouse Model of Osteoporosis

    International journal of molecular sciences15 Oct 2025

More on Estrogens

Inflammation

downin mice1

1 study

  1. Placenta-derived mesenchymal stem cells inhibit inflammation in mice.

    “PD-MSCs also reduced inflammatory cytokine levels while enhancing anti-inflammatory factors.”

    Animalsin an estrogen-deficiency-induced osteoporosis mouse model

    Increased BMP/SMAD Signaling by PD-MSCs Promotes Bone Formation in an Ovariectomized Mouse Model of Osteoporosis

    International journal of molecular sciences15 Oct 2025

More on Inflammation

Bone mineral density

upin mice1

1 study

  1. Placenta-derived mesenchymal stem cells increase bone mineral density in mice.

    “PD-MSC transplantation significantly improved osteoporosis-related parameters, including increased femur weight, bone volume, bone mineral density, and calcium deposition.”

    Animalsin an estrogen-deficiency-induced osteoporosis mouse modelfemur

    Increased BMP/SMAD Signaling by PD-MSCs Promotes Bone Formation in an Ovariectomized Mouse Model of Osteoporosis

    International journal of molecular sciences15 Oct 2025

More on Bone mineral density

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