PKD inhibition

1. PKD inhibition protects against glucose intolerance in mice.

   “protected against high-fat diet-induced glucose and insulin intolerance.”

   Animalsunder high-fat diet conditions

   Protein kinase D deficiency induces a senescence-like phenotype in β-cells and improves glucose and insulin tolerance under high-fat diet conditions

   Molecular metabolism·3 Dec 2025

1. PKD inhibition improves glucose tolerance in mice.

   “PKD inhibition significantly improved glucose tolerance, enhanced glucose-stimulated insulin secretion”

   Animalsin mature adult mice

   Protein kinase D deficiency induces a senescence-like phenotype in β-cells and improves glucose and insulin tolerance under high-fat diet conditions

   Molecular metabolism·3 Dec 2025

1. PKD inhibition decreases SOD2 in mice.

   “These changes were associated with decreased expression of the antioxidant enzyme superoxide dismutase 2 and increased levels of reactive oxygen species.”

   Animalsassociated with PKD inhibition

   Protein kinase D deficiency induces a senescence-like phenotype in β-cells and improves glucose and insulin tolerance under high-fat diet conditions

   Molecular metabolism·3 Dec 2025

More on SOD2

1. PKD inhibition induces cellular senescence in mice.

   “inhibition of PKD activity in mature adult mice induced a senescent-like β-cell phenotype characterized by enlarged cell size and elevated β-galactosidase activity.”

   Animalsin mature adult mice

   Protein kinase D deficiency induces a senescence-like phenotype in β-cells and improves glucose and insulin tolerance under high-fat diet conditions

   Molecular metabolism·3 Dec 2025

More on Cellular senescence