Personalized notification letter

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans1

Outcomes

Systolic blood pressure

downin humans1

1 study

Personalized notification letter decreases systolic blood pressure in humans (–2.8 mm Hg).
“greater incremental SBP reduction at follow-up was also seen among intervention (–2.8 mm Hg; p < 0.0001) but not control donors (–1.2 mm Hg; p=0.15).”
Humansamong antihypertensive medication usersmedian interval = 4 months
From Donation Data to Disease Prevention: Sending 135,000 Letters as a National Outreach by the American Red Cross Improves Hypertension Control
AHA Scientific Sessions 2025 abstract3 Nov 2025

Hypertension control

upin humans1

1 study

Personalized notification letter improves hypertension control in humans (22 % compared with 9 %).
“Guideline level control (SBP < 130 mm Hg) was achieved in 22 % of the intervention group compared with 9 % of controls (p < 0.001).”
Humansmedian interval = 4 months
From Donation Data to Disease Prevention: Sending 135,000 Letters as a National Outreach by the American Red Cross Improves Hypertension Control
AHA Scientific Sessions 2025 abstract3 Nov 2025

Systolic blood pressure reduction

upin humans1

1 study

Personalized notification letter increases systolic blood pressure reduction in humans (53 % versus 27 %).
“At follow-up, SBP was lower in 53 % of letter recipients versus 27 % of controls (Figure, p < 0.001).”
Humansmedian interval = 4 months
From Donation Data to Disease Prevention: Sending 135,000 Letters as a National Outreach by the American Red Cross Improves Hypertension Control
AHA Scientific Sessions 2025 abstract3 Nov 2025

Latest

1 in 12 months

AHA Scientific Sessions 2025 Abstract3 Nov

From Donation Data to Disease Prevention: Sending 135,000 Letters as a National Outreach by the American Red Cross Improves Hypertension Control

Cohort study in peopleHypertension

Paper

Personalized notification letter

Outcomes

Latest

From Donation Data to Disease Prevention: Sending 135,000 Letters as a National Outreach by the American Red Cross Improves Hypertension Control

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