Pericapsular nerve group block
Pericapsular nerve group block has been studied in 2 papers since 2021: 1 trial and 1 observational study in people. The newest paper, Nov 12, 2024: “Effects of pericapsular nerve group block on early postoperative cognitive function in older people undergoing hip arthroplasty: a randomized controlled clinical trial”.
2 papers study it10 findingsUpdated
“the PENG block group had higher MMSE score than the control group at 7 days postoperatively (27.0 ± 1.8 vs. 26.1 ± 1.7, P = 0.048), with a mean difference of 0.9 (95%CI, 0.1-0.9)”
None of its findings points the other way.
- 2 independent labs in 3 countries
- Funders: Medical Health Science and Technology Project of Zhejiang Provincial Health Commission and 1 more
- Human trial1
- Humans1
Studies in people
1 study gave pericapsular nerve group block to people and measured what changed.
up: Improves cognitive function
down: Lowers the risk of perioperative neurocognitive disorder6.7% vs. 30%, RR (95% CI): 0.2 (0.1, 0.9)
down: Decreases postoperative pain
Randomized trial60 peopleage between 65 and 85 yearsup to 7 d
BMC geriatrics, Nov 12, 2024
What did studies of Pericapsular nerve group block find?
5Studies of Pericapsular nerve group block measured 5 outcomes; the most studied are high mobility group box protein 1 (1 study), postoperative pain (1) and cognitive function (1).
High mobility group box protein 1
downin humans1
1 study
High mobility group box protein 1
downin humans1
Pericapsular nerve group block decreases high mobility group box protein 1 in humans.
“Compared with group C, group P resulted in lower HMGB1 levels at 1 day after surgery (P < 0.05; Table ).”
Human trialup to 7 dn = 60
BMC geriatrics
Pericapsular nerve group block decreases high mobility group box protein 1 in humans (P < 0.05).
“Patients in group P showed lower plasma levels of HMGB1 than group C at 1 day after surgery (P < 0.05)”
Human trialafter hip arthroplastyplasma1 dayn = 60
BMC geriatrics
Postoperative pain
downin humans1
1 study
Postoperative pain
downin humans1
Pericapsular nerve group block decreases postoperative pain in humans.
“In group P, the static VAS scores at 6, 12, and 24 h postoperatively were significantly lower than those in group C (P < 0.05), but no intergroup difference was observed at 48 h postoperatively (P > 0.05, Fig. ).”
Human trialup to 7 dn = 60
BMC geriatrics
Pericapsular nerve group block decreases postoperative pain in humans (P < 0.05).
“In group P, the static VAS scores at 6, 12, and 24 h postoperatively were significantly lower than those in group C (all P < 0.05).”
Human trialafter hip arthroplastyn = 60
BMC geriatrics
Cognitive function
upin humans1
1 study
Cognitive function
upin humans1
Pericapsular nerve group block improves cognitive function in humans.
“Compared with group C, the MMSE scores were significantly higher in group P at 7 days postoperatively (P < 0.05).”
Human trialup to 7 dn = 60
BMC geriatrics
Pericapsular nerve group block improves cognitive function in humans (27.0 ± 1.8 vs. 26.1 ± 1.7, MD 0.9 (95% CI 0.1-0.9)).
“the PENG block group had higher MMSE score than the control group at 7 days postoperatively (27.0 ± 1.8 vs. 26.1 ± 1.7, P = 0.048), with a mean difference of 0.9 (95%CI, 0.1-0.9)”
Human trialafter hip arthroplasty7 daysn = 60
BMC geriatrics
Muscle strength
upin humans1
1 study
Muscle strength
upin humans1
Pericapsular nerve group block improves muscle strength in humans (5/5 vs. 2/5, p = 0.001).
“The postoperative muscle strength of the quadriceps was greater in the PENG group than in the Femoral group (5/5 vs. 2/5, p = 0.001).”
Humansquadriceps
Comparison between femoral block and PENG block in femoral neck fractures: A cohort study
PloS one
Morphine consumption
no changein humans1
1 study
Morphine consumption
no changein humans1
Pericapsular nerve group block has no effect on morphine consumption in humans (10 [0-20] mg vs 20 [0-50] mg, p = 0.458).
“The median, postoperative, morphine equivalent consumption at 48 hours was 10 [0-20] mg and 20 [0-50] mg in Femoral and PENG groups respectively (p = 0.458).”
Humans48 hours
Comparison between femoral block and PENG block in femoral neck fractures: A cohort study
PloS one
What is Pericapsular nerve group block linked with?
1Studies link Pericapsular nerve group block with 1 measure, most often perioperative neurocognitive disorder (1 study).
Perioperative neurocognitive disorder
downin humans1
1 study
Perioperative neurocognitive disorder
downin humans1
Pericapsular nerve group block lowers the risk of perioperative neurocognitive disorder in humans (6.7% vs. 30%, RR (95% CI): 0.2 (0.1, 0.9)).
“The incidence of PND in group P at 7 days postoperatively was significantly lower than that in group C [6.7% vs. 30%, RR (95% CI): 0.2 (0.1, 0.9), P = 0.044; Fig. ].”
Human trialup to 7 dn = 60
BMC geriatrics
Pericapsular nerve group block lowers the risk of perioperative neurocognitive disorder in humans (6.7% vs. 30%).
“The incidence of PND at 7 days postoperatively was 6.7% in group P, lower than that of 30% in group C (P = 0.044).”
Human trialafter hip arthroplasty7 daysn = 60
BMC geriatrics