Perfluoroalkane-tethered macrocyclic peptide shuttle
1 paper2 findings
- 1 lab in 1 country
- Funders: Fundamental Research Funds for the Central Universities and 2 more
- Animals1
Outcomes
2Clathrin-mediated endocytosis
upin mice1
1 study
Clathrin-mediated endocytosis
upin mice1
Perfluoroalkane-tethered macrocyclic peptide shuttle activates clathrin-mediated endocytosis in mice.
“actively triggers caveolae-mediated transcytosis, a pathway potentiated in brain endothelial cells during aging”
Animalsbrain
A Chemically Engineered Macrocyclic Peptide Shuttle Overcomes Blood-Brain Barrier in Aging Brain
Angewandte Chemie (International ed. in English)24 Nov 2025
BBB traversal efficiency
upin mice1
1 study
BBB traversal efficiency
upin mice1
Perfluoroalkane-tethered macrocyclic peptide shuttle improves BBB traversal efficiency in mice.
“the perfluoroalkane-tethered macrocycle achieves superior BBB traversal efficiency over current state-of-the-art receptor-mediated BBB peptide shuttles, with high biosafety.”
Animalsin aged murine modelsbrain
A Chemically Engineered Macrocyclic Peptide Shuttle Overcomes Blood-Brain Barrier in Aging Brain
Angewandte Chemie (International ed. in English)24 Nov 2025
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1 in 12 monthsAngewandte Chemie
A Chemically Engineered Macrocyclic Peptide Shuttle Overcomes Blood-Brain Barrier in Aging Brain
Experiments in miceInterventions