Ondansetron

1. Ondansetron inhibits mechanically stimulated NKA release in mice.

   “Ondansetron inhibited mechanically stimulated NKA release in 5-month-old but not 22-month-old colons.”

   Animalsdistal colonfemales

   Age-Related Decreases in Colonic Neurokinin A Content and Release Monitored Using Electrochemical Immunosensors

   Neurogastroenterology and motility·1 Sep 2026

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1. Ondansetron raises the risk of cholecystitis in humans (HR=1.697, 95% CI 1.322-2.177, p<0.0001).

   “cholecystitis (HR=1.697, 95% CI 1.322-2.177, p<0.0001)”

   Humans12 months

   Concurrent Ondansetron Use during Semaglutide Initiation Is Associated with Increased Biliary Complications in a Large Real-World Cohort

   ADA Scientific Sessions 2026 abstract·5 Jun 2026

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1. Ondansetron raises the risk of cholelithiasis in humans (HR=1.501, 95% CI 1.299-1.734, p<0.0001).

   “concurrent ondansetron and semaglutide use was associated with increased risk of cholelithiasis (HR=1.501, 95% CI 1.299-1.734, p<0.0001)”

   Humans12 months

   Concurrent Ondansetron Use during Semaglutide Initiation Is Associated with Increased Biliary Complications in a Large Real-World Cohort

   ADA Scientific Sessions 2026 abstract·5 Jun 2026

More on Cholelithiasis