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Obesity grade 2 or 3

Exposure

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: European Commission and 3 more
  • Humans1

Associations

1

Mortality

upin humans1HR 1.31

1 study

  1. Obesity grade 2 or 3 raises the risk of mortality in humans (HR 1.31, 95%CI 1.02-1.69).

    “having a BMI level greater than 35 kg/m2 increased mortality risk in participants with FI≤0.1 (HR 1.31, 95%CI 1.02-1.69).”

    HumansFI≤0.1 (non-frail)

    Relationship of body mass index with frailty and all-cause mortality among middle-aged and older adults

    BMC medicine24 Oct 2022

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