NUCC-555

1. NUCC-555 inhibits cellular senescence in rat cells.

   “Activin A-stimulated overexpression of cell cycle-/senescence-related genes (e.g., p15INK4b, DEC1, Glb1) was near-completely reversed by NUCC-555 in hepatocytes.”

   Cellsin hepatocytes treated with activin Aliver

   Antagonizing Activin A/p15INK4b Signaling as Therapeutic Strategy for Liver Disease

   Cells·Apr 8, 2024

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1. NUCC-555 decreases liver fibrosis in rats (7.9-fold reduction).

   “Administration of NUCC-555 in rats and mice with progressing fibrosis significantly reduced collagen accumulation (7.9-fold)”

   Animalsin thioacetamide- or carbon tetrachloride-treated rats and miceliver

   Antagonizing Activin A/p15INK4b Signaling as Therapeutic Strategy for Liver Disease

   Cells·Apr 8, 2024

More on Liver fibrosis

1. NUCC-555 increases BrdU in rats (1.9-fold at 18 h and 2.3-fold at 24 h).

   “In partial hepatectomized rats, antagonizing activin A signaling resulted in a 1.9-fold and 2.3-fold increase in BrdU+ cells at 18 and 24 h, respectively.”

   Animalsin partial hepatectomized ratsliver

   Antagonizing Activin A/p15INK4b Signaling as Therapeutic Strategy for Liver Disease

   Cells·Apr 8, 2024

More on BrdU