Nnmt gene restoration

Nnmt gene restoration has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Nov 12, 2026: “Restoring an enzyme improved blood vessel function in aged mice”.

InterventionPreclinical

1 paper studies it2 findingsUpdated Nov 12, 2026

1 new paper in 30 daysSee all 1 papers on nnmt gene restoration

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

1 lab in 1 country

Animals1

What did studies of nnmt gene restoration find?

Studies of nnmt gene restoration measured 2 outcomes: arterial stiffness and vasodilation.

Arterial stiffness

downin mice1

1 study

Nnmt gene restoration decreases arterial stiffness in mice.
“Functional assays demonstrated that NNMT restoration improves vasodilation and arterial stiffness in aged mice, whereas knockdown exacerbates these deficits.”
Animalsendothelial-targeted adeno-associated virus–Tie systemsartery
Restoring an enzyme improved blood vessel function in aged mice
Circulation researchNov 12, 2026

Vasodilation

upin mice1

1 study

Nnmt gene restoration improves vasodilation in mice.
“Functional assays demonstrated that NNMT restoration improves vasodilation and arterial stiffness in aged mice, whereas knockdown exacerbates these deficits.”
Animalsendothelial-targeted adeno-associated virus–Tie systemsvascular endothelium
Restoring an enzyme improved blood vessel function in aged mice
Circulation researchNov 12, 2026

Latest

1 paper in 12 months

Circulation ResearchNov 12

Restoring an enzyme improved blood vessel function in aged mice

Restoring the enzyme NNMT in cells lining blood vessels improved vessel widening and reduced arterial stiffness in aged mice; lowering NNMT worsened both.Restoring the enzyme NNMT in cells lining blood vessels improved vessel widening and reduced arterial stiffness in aged mice; lowering NNMT worsened both.

Mouse studyInterventions

Paper