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Nitric oxide-donating aspirin

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: National Cancer Institute and 1 more
  • Animals1

Outcomes

2

Lifespan

downin mice1upin mice1

1 study

  1. Nitric oxide-donating aspirin shortens lifespan in mice.

    “high-dose NO-ASA (720/1,500 mg/kg) treatments increased tumor burden, decreased life span, and exacerbated MSI uniquely in the LS/HNPCC mouse model.”

    Animalsin a Lynch syndrome mouse model720/1,500 mg/kg

    Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model

    Cancer prevention research (Philadelphia, Pa.)24 Mar 2011

  2. Nitric oxide-donating aspirin extends lifespan in mice (18% to 21%).

    “ASA (400 mg/kg) and low-dose NO-ASA (72 mg/kg) increased life span by 18% to 21%.”

    Animalsin a Lynch syndrome mouse model72 mg/kg

    Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model

    Cancer prevention research (Philadelphia, Pa.)24 Mar 2011

Tumor burden

upin mice1

1 study

  1. Nitric oxide-donating aspirin increases tumor burden in mice.

    “high-dose NO-ASA (720/1,500 mg/kg) treatments increased tumor burden”

    Animalsin a Lynch syndrome mouse model720/1,500 mg/kg

    Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model

    Cancer prevention research (Philadelphia, Pa.)24 Mar 2011

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