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Nerve injury

Intervention

3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Deutsche Forschungsgemeinschaft and 4 more

What did studies of Nerve injury find?

2

Studies of Nerve injury measured 2 outcomes; the most studied are Cdkn1a RNA levels (1 study) and Cdkn2a RNA levels (1).

Cdkn1a RNA levels

upin rats1upin rodent1

1 study

  1. Nerve injury increases Cdkn1a RNA levels in rats.

    “significantly increased Cdkn1a RNA levels in DRG cells from female but not male rats”

    Animalsfollowing nerve injurydorsal root ganglionfemales

    Senescence-associated Cdkn1a (p21) is upregulated in rodent dorsal root ganglion neurons across lesion-based neuropathic pain models

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

  2. Nerve injury increases Cdkn1a RNA levels in rodent.

    “Cdkn1a but not Cdkn2a RNA is significantly increased across different axotomy- and lesion-based neuropathic pain models”

    Animalsacross different axotomy- and lesion-based neuropathic pain modelsdorsal root ganglion

    Senescence-associated Cdkn1a (p21) is upregulated in rodent dorsal root ganglion neurons across lesion-based neuropathic pain models

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

More on Cdkn1a RNA levels

Cdkn2a RNA levels

no changein rodent1

1 study

  1. Nerve injury has no effect on Cdkn2a RNA levels in rodent.

    “Cdkn1a but not Cdkn2a RNA is significantly increased across different axotomy- and lesion-based neuropathic pain models”

    Animalsacross different axotomy- and lesion-based neuropathic pain modelsdorsal root ganglion

    Senescence-associated Cdkn1a (p21) is upregulated in rodent dorsal root ganglion neurons across lesion-based neuropathic pain models

    bioRxiv (Cold Spring Harbor Laboratory)Preprint

More on Cdkn2a RNA levels

Funding

8 grants since 2016

National Institute of Neurological Disorders and StrokeUS$4.4mJapan Society for the Promotion of ScienceJP¥11.4mNatural Science Foundation of Guangdong ProvinceCN¥100k