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Navigation from novel locations

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Alzheimer's Association and 2 more
  • Humans1

Outcomes

1

Location learning performance

downin humans1

1 study

  1. Navigation from novel locations impair location learning performance in humans.

    “Both age groups performed worse when initially learning locations from novel compared with familiar locations”

    Human trialnovel compared with familiar starting locations

    Age differences in spatial navigation stem from a preference for familiar routes rather than impaired landmark-dependent strategies

    Psychology and aging28 Aug 2025

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