Multivitamin-multimineral supplementation

1. Multivitamin-multimineral supplementation decreases metabolomic risk scores in humans (Cohen's d range, -0.206 to -0.277).

   “MVM also reduced MRS for 16 chronic diseases, including major cardiovascular events, renal disease, all-cause dementia, asthma, cataracts, glaucoma, liver disease, non-melanoma skin cancer, and prostate cancer (Cohen's d range, -0.206 to -0.277).”

   Human trial2 yearsn = 399

   Effects of daily multivitamin-multimineral supplementation on metabolomic profiles: 2-year findings from the COSMOS randomized clinical trial

   GeroScience·30 Mar 2026

More on Metabolomic risk scores

1. Multivitamin-multimineral supplementation increases omega-3 fatty acids in humans (Cohen's d 0.193 [0.003 to 0.382]).

   “increased the concentrations of docosahexaenoic acid (Cohen's d for between-group differences in changes from baseline to 2 years, 0.212 [95% CI, 0.02 to 0.404]) and omega-3 fatty acids (0.193 [0.003 to 0.382])”

   Human trial2 yearsn = 399

   Effects of daily multivitamin-multimineral supplementation on metabolomic profiles: 2-year findings from the COSMOS randomized clinical trial

   GeroScience·30 Mar 2026

More on Omega-3 fatty acids

1. Multivitamin-multimineral supplementation increases docosahexaenoic acid in humans (Cohen's d 0.212 [95% CI, 0.02 to 0.404]).

   “Compared with placebo, 2-year daily MVM supplementation increased the concentrations of docosahexaenoic acid (Cohen's d for between-group differences in changes from baseline to 2 years, 0.212 [95% CI, 0.02 to 0.404])”

   Human trial2 yearsn = 399

   Effects of daily multivitamin-multimineral supplementation on metabolomic profiles: 2-year findings from the COSMOS randomized clinical trial

   GeroScience·30 Mar 2026

More on Docosahexaenoic acid