MS023

MS023 improves grip strength in mice.

“the preclinical mouse model of Duchenne muscular dystrophy had increased grip strength with MS023 treatment”

Animalsin preclinical mouse model of Duchenne muscular dystrophy

Inhibition of Type I PRMTs Reforms Muscle Stem Cell Identity Enhancing their Therapeutic Capacity

eLife·May 25, 2023Preprint

MS023 improves grip strength in mice.

“Interestingly, the preclinical mouse model of Duchenne muscular dystrophy had increased grip strength with MS023 treatment.”

Animalspreclinical mouse model of Duchenne muscular dystrophy

Inhibition of Type I PRMTs Reforms Muscle Stem Cell Identity Enhancing their Therapeutic Capacity

bioRxiv (Cold Spring Harbor Laboratory)·Jan 7, 2023Preprint

MS023 improves muscle regeneration in mice.

“Transplantation of MuSCs treated with MS023 had a better ability to repopulate the MuSC niche and contributed efficiently to muscle regeneration following injury”

Animalsfollowing injuryskeletal muscle

Inhibition of Type I PRMTs Reforms Muscle Stem Cell Identity Enhancing their Therapeutic Capacity

eLife·May 25, 2023Preprint

MS023 improves muscle regeneration in mice.

“Transplantation of MuSCs treated with MS023 had a better ability to repopulate the MuSC niche and contributed efficiently to muscle regeneration following injury.”

Animalsfollowing injuryskeletal muscle

Inhibition of Type I PRMTs Reforms Muscle Stem Cell Identity Enhancing their Therapeutic Capacity

bioRxiv (Cold Spring Harbor Laboratory)·Jan 7, 2023Preprint

MS023 increases muSC proliferation in mouse cells.

“inhibition of type I protein arginine methyltransferases (PRMTs) with MS023 increases the proliferative capacity of ex vivo cultured MuSCs”

Cellsskeletal muscle

Inhibition of Type I PRMTs Reforms Muscle Stem Cell Identity Enhancing their Therapeutic Capacity

eLife·May 25, 2023Preprint

MS023 increases proliferation in mouse cells.

“inhibition of type I protein arginine methyltransferases (PRMTs) with MS023 increases the proliferative capacity of ex vivo cultured MuSCs.”

Cellsex vivo cultured MuSCs

Inhibition of Type I PRMTs Reforms Muscle Stem Cell Identity Enhancing their Therapeutic Capacity

bioRxiv (Cold Spring Harbor Laboratory)·Jan 7, 2023Preprint