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Monozukuri program

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Human trial1

Outcomes

2

Verbal ability, attention, processing speed, memory, and working memory

no changein humans1

1 study

  1. Monozukuri program has no effect on verbal ability, attention, processing speed, memory, and working memory in humans.

    “No statistically significant differences were found between groups in the other assessed cognitive domains.”

    Human trialCompared with health-related educational lectures in community-dwelling older adults12 weekly sessionsn = 51

    The Effects of the MONOZUKURI Program on Executive Function Among Community-Dwelling Older Adults: A Randomized Controlled Trial

    Brain and behavior27 Sep 2025

Executive function

upin humans1

1 study

  1. Monozukuri program improves executive function in humans.

    “a significant group difference was detected in the change scores of the Trail Making Test Part B, which assesses executive function, indicating greater improvement in the IG.”

    Human trialCompared with health-related educational lectures in community-dwelling older adults12 weekly sessionsn = 51

    The Effects of the MONOZUKURI Program on Executive Function Among Community-Dwelling Older Adults: A Randomized Controlled Trial

    Brain and behavior27 Sep 2025

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