Moderate-intensity aerobic training
2 papers8 findings
- 2 independent labs in 2 countries
- Funders: National Center for Research Resources and 2 more
- Human trial2
Outcomes
8Serine
downin humans1
1 study
Serine
downin humans1
Moderate-intensity aerobic training decreases serine in humans.
“decreases in specific phosphatidylcholines species (PC O-30:2, PC O-28:0, PC O-30:0, PC 42:2, LPC 26:0), the amino acid serine”
Human trialserum8 weeksfemalesn = 39
Exercise triggers integrated lipid, sphingolipid and purine metabolic alterations in midlife women
Frontiers in physiology5 Aug 2026
Xanthine
upin humans1
1 study
Xanthine
upin humans1
Moderate-intensity aerobic training increases xanthine in humans.
“post-exercise upregulation of dihydroceramides, glycosylceramides, ceramides, acylcarnitines (e.g., C14:2, C3-DC/C4-OH), diacylglycerols(DG 16:0_20:4, DG O-18:2_18:2),triacylglycerols, selected cholesterol esters (e.g., CE 20:3), cystine, and the nucleobase-related metabolite xanthine”
Human trialserum8 weeksfemalesn = 39
Exercise triggers integrated lipid, sphingolipid and purine metabolic alterations in midlife women
Frontiers in physiology5 Aug 2026
Acylcarnitines
upin humans1
1 study
Acylcarnitines
upin humans1
Moderate-intensity aerobic training increases acylcarnitines in humans.
“Univariate analysis revealed a coordinated post-exercise upregulation of dihydroceramides, glycosylceramides, ceramides, acylcarnitines”
Human trialserum8 weeksfemalesn = 39
Exercise triggers integrated lipid, sphingolipid and purine metabolic alterations in midlife women
Frontiers in physiology5 Aug 2026
Ceramide
upin humans1
1 study
Ceramide
upin humans1
Moderate-intensity aerobic training increases ceramide in humans.
“Univariate analysis revealed a coordinated post-exercise upregulation of dihydroceramides, glycosylceramides, ceramides, acylcarnitines (e.g., C14:2, C3-DC/C4-OH), diacylglycerols(DG 16:0_20:4, DG O-18:2_18:2),triacylglycerols, selected cholesterol esters (e.g., CE 20:3), cystine, and the nucleobase-related metabolite xanthine”
Human trialserum8 weeksfemalesn = 39
Exercise triggers integrated lipid, sphingolipid and purine metabolic alterations in midlife women
Frontiers in physiology5 Aug 2026
Insulin response to oral glucose tolerance test
no changein humans1
1 study
Insulin response to oral glucose tolerance test
no changein humans1
Moderate-intensity aerobic training has no effect on insulin response to oral glucose tolerance test in humans.
“This improvement in glucose response occurred, however, only in those with impaired glucose tolerance at baseline and without any observed change in insulin response.”
Human trialParticipants with improved glucose response had impaired glucose tolerance at baseline.mini-trampoline exercise4 months
Journal of the American Geriatrics Society1 Jul 1998
Incremental glucose area under the curve
downin humans1−25%
1 study
Incremental glucose area under the curve
downin humans1−25%
Moderate-intensity aerobic training decreases incremental glucose area under the curve in humans (-25%).
“the incremental area under the glucose curve decreased by 25% (P < .05).”
Human trialImprovement occurred only in participants with impaired glucose tolerance at baseline.mini-trampoline exercise4 months
Journal of the American Geriatrics Society1 Jul 1998
Abdominal fat
no changein humans1
1 study
Abdominal fat
no changein humans1
Moderate-intensity aerobic training has no effect on abdominal fat in humans.
“training had no effect on abdominal fat.”
Human trialmini-trampoline exerciseabdominal adipose tissue4 monthsn = 9
Journal of the American Geriatrics Society1 Jul 1998
VO2 peak
upin humans1+16%
1 study
VO2 peak
upin humans1+16%
Moderate-intensity aerobic training increases VO2 peak in humans (+16%).
“Aerobic training resulted in a 16% increase in VO2 peak and a 24% decrease in FFA in the T group (P < .05)”
Human trialmini-trampoline exercise4 times a week for 60-minute sessions; 55–65% of HRmax for 1 month, then 75% for 3 months4 monthsn = 9
Journal of the American Geriatrics Society1 Jul 1998