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MIT-001

Intervention

1 paper6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: Ministry of SMEs and Startups
  • Cells1

Outcomes

6

Oxygen consumption rate

upin mouse cells1

1 study

  1. MIT-001 increases oxygen consumption rate in mouse cells.

    “MIT-001 enhanced the mitochondrial membrane potential and oxygen consumption rate”

    Cellsembryos derived from aged female BDF1 micepreimplantation embryo

    MIT-001 ameliorates ferroptosis-induced mitochondrial dysfunction and enhances embryo quality in preimplantation embryos from aged female mice

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie9 Aug 2025

More on Oxygen consumption rate

Mitochondrial membrane potential

upin mouse cells1

1 study

  1. MIT-001 increases mitochondrial membrane potential in mouse cells.

    “MIT-001 enhanced the mitochondrial membrane potential and oxygen consumption rate”

    Cellsembryos derived from aged female BDF1 micepreimplantation embryo

    MIT-001 ameliorates ferroptosis-induced mitochondrial dysfunction and enhances embryo quality in preimplantation embryos from aged female mice

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie9 Aug 2025

More on Mitochondrial membrane potential

Blastocyst formation rate

upin mouse cells1

1 study

  1. MIT-001 increases blastocyst formation rate in mouse cells.

    “Embryos treated with MIT-001 showed significantly improved developmental progression and increased blastocyst formation rates compared with untreated controls.”

    Cellsembryos derived from aged female BDF1 mice; compared with untreated controlspreimplantation embryo

    MIT-001 ameliorates ferroptosis-induced mitochondrial dysfunction and enhances embryo quality in preimplantation embryos from aged female mice

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie9 Aug 2025

Estradiol synthesis

upin human cells1

1 study

  1. MIT-001 increases estradiol synthesis in human cells.

    “MIT-001 effectively protected against Ras-selective lethal 3 (RSL3)-induced ferroptosis, restored cell viability, and recovered estradiol synthesis”

    CellsRSL3-induced ferroptosisKGN cells

    MIT-001 ameliorates ferroptosis-induced mitochondrial dysfunction and enhances embryo quality in preimplantation embryos from aged female mice

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie9 Aug 2025

Cell viability

upin human cells1

1 study

  1. MIT-001 increases cell viability in human cells.

    “MIT-001 effectively protected against Ras-selective lethal 3 (RSL3)-induced ferroptosis, restored cell viability, and recovered estradiol synthesis”

    CellsRSL3-induced ferroptosisKGN cells

    MIT-001 ameliorates ferroptosis-induced mitochondrial dysfunction and enhances embryo quality in preimplantation embryos from aged female mice

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie9 Aug 2025

Ferroptosis

downin human cells1

1 study

  1. MIT-001 protects against ferroptosis in human cells.

    “MIT-001 effectively protected against Ras-selective lethal 3 (RSL3)-induced ferroptosis”

    CellsRSL3-induced ferroptosisKGN cells

    MIT-001 ameliorates ferroptosis-induced mitochondrial dysfunction and enhances embryo quality in preimplantation embryos from aged female mice

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie9 Aug 2025

More on Ferroptosis

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