peb
Gene1 paper2 findingsNCBI Gene 31391Taxon 7227
- Model organisms1
Effects
2Motor deficits
downin flies1
1 study
Motor deficits
downin flies1
peb protects against motor deficits in flies.
Model organismsshown by loss of peb
RAS/MAPK overactivation drives motor axon loss in flies · iScience · 21 Sep 2026
Motor axonal and NMJ degeneration
downin flies1
1 study
Motor axonal and NMJ degeneration
downin flies1
peb prevents motor axonal and NMJ degeneration in flies.
Model organismsshown by loss of peb
RAS/MAPK overactivation drives motor axon loss in flies · iScience · 21 Sep 2026
Latest
1RAS/MAPK overactivation drives motor axon loss in flies
An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues…An unbiased genetic screen in Drosophila revealed that excessive RAS/MAPK signaling causes adult-onset neurodegeneration that a MEK inhibitor rescues in a dose-dependent manner.