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Methionine, tryptophan, and niacin restriction

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Institute of Genetics and 3 more
  • 2 of 2 findings with company ties
  • Animals1

Outcomes

2

Lactobacillus relative abundance

upin mice1

1 study

  1. Methionine, tryptophan, and niacin restriction increases Lactobacillus relative abundance in mice.

    “with an increased relative abundance of Lactobacillus species observed in some cases”

    Animalsintestinefemales

    Deficiencies in methionine, tryptophan, and niacin remodels intestinal transcriptome and gut microbiota in female mice

    Scientific reports16 Oct 2025

More on Lactobacillus relative abundance

Immune cell populations

upin mice1

1 study

  1. Methionine, tryptophan, and niacin restriction increases immune cell populations in mice.

    “dietary restriction of those nutrients led to an increase in intestinal immune cell populations”

    Animalsintestinefemales

    Deficiencies in methionine, tryptophan, and niacin remodels intestinal transcriptome and gut microbiota in female mice

    Scientific reports16 Oct 2025

More on Immune cell populations

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