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METALLOTHIONEIN-2

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Motor Neurone Disease Research Institute of Australia
  • Animals1

Outcomes

2

Disease onset

upin mice1

1 study

  1. METALLOTHIONEIN-2 increases disease onset in mice (around 4%).

    “Mixed model body weight trajectories over time indicated that MT2-treated mice, with or without exercise, reached maximum body weight at a later age, suggesting a delay in disease onset of around 4% compared to saline-treated mice.”

    Animalsin SOD1G93A familial ALS miceinjection, i.m.females

    The influence of metallothionein treatment and treadmill running exercise on disease onset and survival in SOD1G93A amyotrophic lateral sclerosis mice

    The European journal of neuroscience30 Jan 2020

Lifespan

upin mice1

1 study

  1. METALLOTHIONEIN-2 extends lifespan in mice (around 3% longer).

    “MT2-treated mice survived around 3% longer than vehicle-treated mice, with this mild effect reaching statistical significance in Cox proportional hazards analysis once adjusted for potential confounders.”

    Animalsin SOD1G93A familial ALS miceinjection, i.m.females

    The influence of metallothionein treatment and treadmill running exercise on disease onset and survival in SOD1G93A amyotrophic lateral sclerosis mice

    The European journal of neuroscience30 Jan 2020

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