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Menopausal transition

Menopausal transition has been studied in 2 papers since 2017: 2 observational studies in people. The newest paper, Aug 7, 2023: “Substantial Lipid Increases During Menopausal Transition in Korean Middle-Aged Women”.

Exposure

2 papers study it5 findingsUpdated

See all 2

“high-density lipoprotein cholesterol (HDL-C) levels increased at 0.42 mg/dL per year (95% confidence interval [CI], 0.29 to 0.55 mg/dL).”
Substantial Lipid Increases During Menopausal Transition in Korean Middle-Aged WomenJournal of Korean medical science2023doi:10.3346/jkms.2023.38.e238

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Korea Disease Control and Prevention Agency and 7 more
  • Humans2

What did studies of Menopausal transition find?

5

Studies of Menopausal transition measured 5 outcomes; the most studied are non-HDL-C to HDL-C ratio (1 study), non-HDL-C (1) and HDL-C (1).

Non-HDL-C to HDL-C ratio

upin humans1

1 study

  1. Menopausal transition increases non-HDL-C to HDL-C ratio in humans (0.05 (95% CI, 0.04 to 0.06)).

    “an annual change in the non-HDL-C to HDL-C ratio was 0.05 (95% CI, 0.04 to 0.06).”

    Humans15.76 yearsfemalesn = 1,436

    Substantial Lipid Increases During Menopausal Transition in Korean Middle-Aged Women

    Journal of Korean medical science

More on Non-HDL-C to HDL-C ratio

Non-HDL-C

upin humans1

1 study

  1. Menopausal transition increases non-HDL-C in humans (3.42 mg/dL per year (95% CI, 3.11 to 3.72 mg/dL)).

    “non-HDL-C levels simultaneously increased at 3.42 mg/dL per year (95% CI, 3.11 to 3.72 mg/dL)”

    Humans15.76 yearsfemalesn = 1,436

    Substantial Lipid Increases During Menopausal Transition in Korean Middle-Aged Women

    Journal of Korean medical science

More on Non-HDL-C

HDL-C

upin humans1

1 study

  1. Menopausal transition increases HDL-C in humans (0.42 mg/dL per year (95% CI, 0.29 to 0.55 mg/dL)).

    “high-density lipoprotein cholesterol (HDL-C) levels increased at 0.42 mg/dL per year (95% confidence interval [CI], 0.29 to 0.55 mg/dL).”

    Humans15.76 yearsfemalesn = 1,436

    Substantial Lipid Increases During Menopausal Transition in Korean Middle-Aged Women

    Journal of Korean medical science

More on HDL-C

Total volumetric bone mineral density

no changein humans1

1 study

  1. Menopausal transition has no effect on total volumetric bone mineral density in humans.

    “The rate of change in bone density was not different between peri- and post-menopausal women.”

    Humansrate of change compared with post-menopausal womenbone6 yearsfemales

    Cortical porosity exhibits accelerated rate of change in peri- compared with post-menopausal women

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

More on Total volumetric bone mineral density

Cortical porosity

upin humans1

1 study

  1. Menopausal transition increases cortical porosity in humans (+9% per year vs +6% per year).

    “Peri-menopausal women had a + 9% per year increase in Ct.Po, but this increase was slower for post-menopausal women at +6% per year (p = 0.049).”

    Humanscompared with post-menopausal womentibia6 yearsfemales

    Cortical porosity exhibits accelerated rate of change in peri- compared with post-menopausal women

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

More on Cortical porosity

Funding

4 grants since 2018

National Institute of Diabetes and Digestive and Kidney DiseasesUS$2.1mNational Institute of Arthritis and Musculoskeletal and Skin DiseasesUS$1.3mNational Institute of Environmental Health SciencesUS$1.8m

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