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Meloxicam + tramadol

Meloxicam + tramadol has been studied in 1 paper since 2016: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Feb 24, 2016: “Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis”.

Intervention

1 paper studies it3 findingsUpdated

PubChemPubChemChEBIChEBI

See all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Abbott Animal Health and 2 more
  • 3 of 3 findings with company ties
  • Animals1

What did studies of Meloxicam + tramadol find?

3

Studies of Meloxicam + tramadol measured 3 outcomes; the most studied are central hypersensitivity (1 study), motor activity (1) and peak vertical force (1).

Central hypersensitivity

downin F. catus1

1 study

  1. Meloxicam + tramadol decreases central hypersensitivity in F. catus (naturally occurring osteoarthritis; compared with meloxicam alone) (RMTS cut-off reached in 5 cats with combination versus 1 with meloxicam alone).

    “The tramadol-meloxicam combination provided no evident benefit over meloxicam alone, except for central hypersensitivity (assessed with RMTS).”

    Animalsnaturally occurring osteoarthritis; compared with meloxicam alone3 weeksn = 8

    Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis

    Veterinary anaesthesia and analgesia

Motor activity

no changein F. catus1

1 study

  1. Meloxicam + tramadol showed no clear effect on motor activity in F. catus (naturally occurring osteoarthritis).

    “Motor activity increased in M (from 43 ± 12 to 56 ± 13; p = 0.02), but not in TM.”

    Animalsnaturally occurring osteoarthritis3 weeksn = 8

    Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis

    Veterinary anaesthesia and analgesia

Peak vertical force

upin F. catus1

1 study

  1. Meloxicam + tramadol increases peak vertical force in F. catus (naturally occurring osteoarthritis) (51.8 ± 5.0% to 64.1 ± 6.5% of body weight; no difference between groups).

    “peak vertical force (percentage of body weight) increased significantly in both groups (p = 0.02)”

    Animalsnaturally occurring osteoarthritistramadol: 3 mg kg−1 every 12 hours; meloxicam: approximately 0.05 mg kg−1 every 24 hours3 weeksn = 8

    Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis

    Veterinary anaesthesia and analgesia

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