Manganese chloride

1. Manganese chloride has no effect on [3H]quinuclidinyl benzilate binding in rats.

   “whereas [3H]quinuclidinyl benzilate binding was not affected.”

   Animalsfrom conception till adulthoodstriatal membranes1 mg MnCl2 X 4H2O per ml of drinking water

   [3H]spiperone and [3H]quinuclidinyl benzilate binding in striatal membranes from rats chronically treated with manganese chloride throughout development and for over two years

   General pharmacology·1 Jan 1986

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1. Manganese chloride decreases [3H]spiperone binding in rats.

   “Chronic treatment of rats with manganese (1 mg MnCl2 X 4H2O per ml of drinking water) from conception till adulthood only slightly decreased [3H]spiperone binding in striatal membranes”

   Animalsfrom conception till adulthoodstriatal membranes1 mg MnCl2 X 4H2O per ml of drinking water

   [3H]spiperone and [3H]quinuclidinyl benzilate binding in striatal membranes from rats chronically treated with manganese chloride throughout development and for over two years

   General pharmacology·1 Jan 1986

More on [3H]spiperone binding

1. Manganese chloride decreases NAD-linked isocitrate dehydrogenase activity in rats.

   “treatment with a high dose (10 mg MnCl2.4H2O per ml) resulted in transient but age-dependent decreases in the activities of this enzyme”

   Animalscerebral cortex and mid-brain10 mg MnCl2.4H2O per ml

   Differences in the neurotoxic effects of manganese during development and aging: some observations on brain regional neurotransmitter and non-neurotransmitter metabolism in a developmental rat model of chronic manganese encephalopathy

   Neurotoxicology·1 Jan 1984

More on NAD-linked isocitrate dehydrogenase activity

1. Manganese chloride decreases choline acetyltransferase in rats.

   “Mn-treatment in development led to small decreases in choline acetyltransferase activities in cerebellum and mid-brain of 2 month old rats”

   Animalscerebellum and mid-brain

   Differences in the neurotoxic effects of manganese during development and aging: some observations on brain regional neurotransmitter and non-neurotransmitter metabolism in a developmental rat model of chronic manganese encephalopathy

   Neurotoxicology·1 Jan 1984

More on Choline acetyltransferase

1. Manganese chloride decreases synaptosomal dopamine uptake in rats.

   “In development Mn-treatment led to transient but age-dependent decreases in synaptosomal dopamine uptake in hypothalamus, striatum and mid-brain”

   Animalsbrain

   Differences in the neurotoxic effects of manganese during development and aging: some observations on brain regional neurotransmitter and non-neurotransmitter metabolism in a developmental rat model of chronic manganese encephalopathy

   Neurotoxicology·1 Jan 1984

More on Synaptosomal dopamine uptake

1. Manganese chloride is associated with age-related changes in activities of several enzymes in rats.

   “Lifespan Mn-treatment (1 mg MnCl2.4H2O per ml) exerted antagonistic effects on the age-related changes in activities of several enzymes.”

   Animalsover 2 years

   Differences in the neurotoxic effects of manganese during development and aging: some observations on brain regional neurotransmitter and non-neurotransmitter metabolism in a developmental rat model of chronic manganese encephalopathy

   Neurotoxicology·1 Jan 1984