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M5

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Canadian Institutes of Health Research and 2 more
  • 3 of 3 findings with company ties
  • Human trial1

Outcomes

3

Physical function

upin humans1

1 study

  1. M5 improves physical function in humans (-10.5% vs. +1.1%).

    “performance (4-Step-Stair-Climb time; -10.5% vs. +1.1%) vs. the PLA group (p < 0.05).”

    Human trialoverweight/obese participants with at least one other MetS risk factor3 monthsmales

    Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrospective Analysis of a Randomized Clinical Trial with Implications for Aging, Sarcopenic Obesity, and Weight Management

    NutrientsDec 23, 2024

Muscle strength

upin humans1

1 study

  1. M5 improves muscle strength in humans (+17% vs. -1.4%).

    “strength (leg press; +17% vs. -1.4%), and performance (4-Step-Stair-Climb time; -10.5% vs. +1.1%) vs. the PLA group (p < 0.05).”

    Human trialoverweight/obese participants with at least one other MetS risk factor3 monthsmales

    Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrospective Analysis of a Randomized Clinical Trial with Implications for Aging, Sarcopenic Obesity, and Weight Management

    NutrientsDec 23, 2024

Appendicular skeletal muscle mass

upin humans1

1 study

  1. M5 increases appendicular skeletal muscle mass in humans (+2% vs. -0.8%).

    “The M5 group showed greater improvements in LM (ASM; +2% vs. -0.8%), LM/body fat ratios (ASM/FM; +3.8% vs. -5.1%), allometric LM (ASM/BMI; +1.2% vs. -2.5%)”

    Human trialoverweight/obese participants with at least one other MetS risk factor3 monthsmales

    Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrospective Analysis of a Randomized Clinical Trial with Implications for Aging, Sarcopenic Obesity, and Weight Management

    NutrientsDec 23, 2024

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