Lymphocytic choriomeningitis virus
4 findings
- 1 lab in 1 country
- Funders: Australian Research Council and 1 more
Outcomes
4Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
Lymphocytic choriomeningitis virus decreases cellular senescence in mice.
“coincident with an attenuation of the senescent TVM cell phenotype”
Animals
LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset
iScience28 Oct 2025
T cell receptor responsiveness
upin mice1
1 study
T cell receptor responsiveness
upin mice1
Lymphocytic choriomeningitis virus improves T cell receptor responsiveness in mice.
“enhanced TCR sensitivity observed up to 18 months post infection, coincident with an attenuation of the senescent TVM cell phenotype”
Animalspersisted into advanced age
LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset
iScience28 Oct 2025
TN cell count
downin mice1
1 study
TN cell count
downin mice1
Lymphocytic choriomeningitis virus decreases TN cell count in mice.
“infection with lymphocytic choriomeningitis virus (LCMV) resulted in a rapid and profound depletion of TVM and true naive (TN) cells”
Animalsinfection
LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset
iScience28 Oct 2025
TVM cell count
downin mice1
1 study
TVM cell count
downin mice1
Lymphocytic choriomeningitis virus decreases TVM cell count in mice.
“infection with lymphocytic choriomeningitis virus (LCMV) resulted in a rapid and profound depletion of TVM and true naive (TN) cells”
Animalsinfection
LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset
iScience28 Oct 2025