Lymphocytic choriomeningitis virus

Intervention

4 findings

  • 1 lab in 1 country
  • Funders: Australian Research Council and 1 more

Outcomes

4

Cellular senescence

downin mice1

1 study
  1. Lymphocytic choriomeningitis virus decreases cellular senescence in mice.

    “coincident with an attenuation of the senescent TVM cell phenotype”

    Animals

    LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset

    iScience28 Oct 2025

More on Cellular senescence

T cell receptor responsiveness

upin mice1

1 study
  1. Lymphocytic choriomeningitis virus improves T cell receptor responsiveness in mice.

    “enhanced TCR sensitivity observed up to 18 months post infection, coincident with an attenuation of the senescent TVM cell phenotype”

    Animalspersisted into advanced age

    LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset

    iScience28 Oct 2025

TN cell count

downin mice1

1 study
  1. Lymphocytic choriomeningitis virus decreases TN cell count in mice.

    “infection with lymphocytic choriomeningitis virus (LCMV) resulted in a rapid and profound depletion of TVM and true naive (TN) cells”

    Animalsinfection

    LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset

    iScience28 Oct 2025

More on TN cell count

TVM cell count

downin mice1

1 study
  1. Lymphocytic choriomeningitis virus decreases TVM cell count in mice.

    “infection with lymphocytic choriomeningitis virus (LCMV) resulted in a rapid and profound depletion of TVM and true naive (TN) cells”

    Animalsinfection

    LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset

    iScience28 Oct 2025

More on TVM cell count