1 paper2 findings
Dopamine release
upin mice1
LRRK2 inhibitors increase dopamine release in mice.
“potentiated DA release more in middle-aged females than males.”
Animalswild-type mice; greater potentiation in females than malesstriatumacute
Inhibition reversed dopamine release deficits in midlife mutant mice
bioRxiv16 Oct 2026Preprint
Sex differences in striatal glutamate and dopamine release
mixedin mice1
LRRK2 inhibitors are associated with sex differences in striatal glutamate and dopamine release in mice.
“Acute inhibition reversed basal sex differences in striatal glutamate and DA release in aged mice”
Animalswild-type micestriatumacute
Inhibition reversed dopamine release deficits in midlife mutant mice
bioRxiv16 Oct 2026Preprint
Two hours of enzyme inhibition reversed dopamine release deficits in middle-aged male and female mice carrying a mutation linked to Parkinson’s disease.Two hours of enzyme inhibition reversed dopamine release deficits in middle-aged male and female mice carrying a mutation linked to Parkinson’s disease.