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LNC81 knockdown

InterventionPreclinical

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

2

Apoptosis

upin mouse cells1

1 study

  1. LNC81 knockdown increases apoptosis in mouse cells.

    “(ii) Promoted apoptosis (indicated by increased BAX/BCL-2 ratio and elevated TUNEL-positive cells).”

    Cellslnc81 knockdown in GCs

    The Age-Associated Long Noncoding RNA lnc81 Regulates Ovarian Granulosa Cell Proliferation and Apoptosis Through TEAD2-CCN1/2 Pathway in Mice

    Journal of cellular physiology1 Sep 2025

More on Apoptosis

Cell proliferation

downin mouse cells1

1 study

  1. LNC81 knockdown decreases cell proliferation in mouse cells.

    “Functional characterization showed that lnc81 knockdown in GCs significantly: (i) Inhibited cellular proliferation”

    Cellslnc81 knockdown in GCs

    The Age-Associated Long Noncoding RNA lnc81 Regulates Ovarian Granulosa Cell Proliferation and Apoptosis Through TEAD2-CCN1/2 Pathway in Mice

    Journal of cellular physiology1 Sep 2025

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