Limb amputation

Intervention3 findings

Outcomes

2

Protease/extracellular matrix proteins

upin A. mexicanum1Very low certainty

1 study

  1. Limb amputation increases protease/extracellular matrix proteins in A. mexicanum.

    Animalsearly limb regenerationperilymph-cerebrospinal fluid

    Multi-omic characterization of axolotl perilymph-cerebrospinal fluid reveals shifts in composition during limb regeneration · bioRxiv · 28 Aug 2026 · Preprint

Protease/extracellular matrix proteins →

Sarcomeric muscle proteins

upin A. mexicanum1Very low certainty

1 study

  1. Limb amputation increases sarcomeric muscle proteins in A. mexicanum.

    Animalsearly limb regenerationperilymph-cerebrospinal fluid

    Multi-omic characterization of axolotl perilymph-cerebrospinal fluid reveals shifts in composition during limb regeneration · bioRxiv · 28 Aug 2026 · Preprint

Sarcomeric muscle proteins →

Associations

1

Oxidative stress and ROS signalling

mixedin A. mexicanum1Very low certainty

1 study

  1. Limb amputation is associated with oxidative stress and ROS signalling in A. mexicanum.

    Animalsearly limb regenerationperilymph-cerebrospinal fluid

    Multi-omic characterization of axolotl perilymph-cerebrospinal fluid reveals shifts in composition during limb regeneration · bioRxiv · 28 Aug 2026 · Preprint

Oxidative stress and ROS signalling →

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