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L-beta-aminoisobutyric acid

Intervention

1 paper3 findings

PubChem 439434ChEBI 33094

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Center for Research Resources and 3 more
  • Animals1

Outcomes

3

Trabecular thickness

upin mice1

1 study

  1. L-beta-aminoisobutyric acid increases trabecular thickness in mice.

    “higher trabecular thickness, and connectivity, smaller bone diameter and Moment of Inertia, but higher Modulus of Elasticity than CTRL (p<0.05)”

    Animalscombined with voluntary wheel runningbone100mg/kg/daythree monthsmales

    L-β-aminoisobutyric acid (L-BAIBA) in combination with voluntary wheel running exercise enhances musculoskeletal properties in middle-age male mice

    Aging1 Oct 2025

Bone marrow adiposity

downin mice1

1 study

  1. L-beta-aminoisobutyric acid decreases bone marrow adiposity in mice.

    “In bone, VWR+L-BAIBA but not VWR showed lower bone marrow adiposity”

    Animalscombined with voluntary wheel runningbone100mg/kg/daythree monthsmales

    L-β-aminoisobutyric acid (L-BAIBA) in combination with voluntary wheel running exercise enhances musculoskeletal properties in middle-age male mice

    Aging1 Oct 2025

More on Bone marrow adiposity

Muscle force

upin mice1

1 study

  1. L-beta-aminoisobutyric acid improves muscle force in mice.

    “Soleus muscles from VWR+L-BAIBA, but not VWR, were larger, contracted more forcefully, and contained more slow-oxidative type I myofibers compared to CTRL (p<0.05).”

    Animalscombined with voluntary wheel runningsoleus muscle100mg/kg/daythree monthsmales

    L-β-aminoisobutyric acid (L-BAIBA) in combination with voluntary wheel running exercise enhances musculoskeletal properties in middle-age male mice

    Aging1 Oct 2025

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