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Koumine

Intervention

1 paper studies it3 findings

PubChemMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • 3 of 3 findings with company ties
  • Animals1

Outcomes

3

NF-κB signaling

downin cells1

1 study

  1. Koumine inhibits NF-κB signaling in cells.

    “our study indicated that KM inhibits early NF-κB activation and receptor activator of NF-κB ligand induced ubiquitination”

    CellsRANKL-induced

    Koumine inhibits RANKL-induced ubiquitination and NF-κB activation to prevent ovariectomy and aging-induced bone loss

    Journal of cellular biochemistryNov 30, 2023

More on NF-κB signaling

Osteoporosis

downin animals1

1 study

  1. Koumine prevents osteoporosis.

    “Moreover, KM prevented OVX-induced OP in vivo”

    AnimalsOVX-induced

    Koumine inhibits RANKL-induced ubiquitination and NF-κB activation to prevent ovariectomy and aging-induced bone loss

    Journal of cellular biochemistryNov 30, 2023

More on Osteoporosis

Bone resorption

downin cells1

1 study

  1. Koumine inhibits bone resorption in cells.

    “The results showed that KM inhibited bone resorption and tartrate-resistant acid phosphatase positive (TRAP+) osteoclasts development by mature osteoclasts in a dose-dependent manner.”

    Cellsby mature osteoclasts

    Koumine inhibits RANKL-induced ubiquitination and NF-κB activation to prevent ovariectomy and aging-induced bone loss

    Journal of cellular biochemistryNov 30, 2023

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