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K35

Intervention

1 paper2 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

2

Cellular senescence

downin mouse cells1

1 study

  1. K35 decreases cellular senescence in mouse cells.

    “we identify two compounds, K35 and its analog K27, capable of dissolving PKM2 aggregates and alleviating senescence”

    Cells

    PKM2 aggregation drives metabolism reprograming during aging process

    Nature communications9 Jul 2024

More on Cellular senescence

Lifespan

upin mice1

1 study

  1. K35 extends lifespan in mice.

    “treatment with K35 and K27 not only alleviate aging-associated signatures but also extend the lifespan of naturally and prematurely aged mice”

    Animalsnaturally and prematurely aged

    PKM2 aggregation drives metabolism reprograming during aging process

    Nature communications9 Jul 2024

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