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Jak inhibitor

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Biotechnology and Biological Sciences Research Council and 3 more
  • Animals1

Outcomes

3

Senescence-associated secretory phenotype (SASP)

downin human cells1

1 study

  1. Jak inhibitor inhibits senescence-associated secretory phenotype (SASP) in human cells.

    “Senescent human primary preadipocytes as well as human umbilical vein endothelial cells (HUVECs) developed a SASP that could be suppressed by targeting the JAK pathway using RNAi or JAK inhibitors.”

    Cellsadipose tissue

    JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

    Proceedings of the National Academy of Sciences of the United States of America2 Nov 2015

More on Senescence-associated secretory phenotype (SASP)

Physical function

upin mice1

1 study

  1. Jak inhibitor improves physical function in mice.

    “The administration of JAK inhibitor to aged mice for 10 wk alleviated both adipose tissue and systemic inflammation and enhanced physical function.”

    Animals10 wk

    JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

    Proceedings of the National Academy of Sciences of the United States of America2 Nov 2015

Inflammation

downin mice1

1 study

  1. Jak inhibitor decreases inflammation in mice.

    “The administration of JAK inhibitor to aged mice for 10 wk alleviated both adipose tissue and systemic inflammation”

    Animals10 wk

    JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

    Proceedings of the National Academy of Sciences of the United States of America2 Nov 2015

More on Inflammation

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